Production of Crystalline Powders for Inhalation Drug Delivery Using Supercritical Fluid Technology
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چکیده
The present study involves typical asthmatic drugs such as salmeterol xinafoate, terbutaline sulphate and fenoterol hydrobromide and represents an approach by which the direct preparation of powders for respiratory formulations using crystallization in supercritical CO2 is optimised on the basis of product material properties. Comparative analysis between micronised and supercritically-produced powders was carried out to define the surface and aerodynamic particle characteristics responsible for performance of these compounds in aerosol tests. Particle size measurements were carried out using laser diffraction and time-offlight measurements, powder surface energetics was determined using inverse gas chromatography (IGC) and analysis of fine particle fraction was performed using a cascade impactor technique. It is shown that reduced surface energy of supercritically-produced particles, related to their low adhesion, plays an important role in the superior performance of these particles in the dry-powder formulation.
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تاریخ انتشار 2003